Endocrine Abstracts

Management of ACC is difficult. Diagnosis usually occurs at an advanced disease stage. Resection of localised disease offers a potential cure, but recurrence is common (75-85% of cases). For the treatment of unresectable/metastatic disease, mitotane is the only approved drug, alongside M-EDP chemotherapy. Mitotane has a narrow therapeutic window and is poorly tolerated. Additionally, ACC is a heterogenous disease regarding phenotype, genotype, disease progression and resistanc...

Obesity is associated with increased and dysfunctional white adipose tissue (WAT). Pharmacological approaches of obesity are still far from obtaining a stable weight loss. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been proposed as anti-obesity drugs due to their effects on weight loss. Furthermore, dual agonists engaging both GLP-1 and glucagon are currently under investigation for their marked effects on weight loss, although their mechanisms of action is stil...